Cyanocobalamin Injection

Innovative Weight & Metabolic Support

Cleveland Care Clinic Highlights Semaglutide / Cyanocobalamin Injection from Empower Pharmacy

When it comes to medically supervised weight loss and metabolic care, Cleveland Care Clinic stays ahead by partnering with trusted compounding pharmacies. One such option gaining attention is Semaglutide / Cyanocobalamin Injection, offered by Empower Pharmacy. In this post, we’ll explore what it is, how it works, pros and cautions, and how we may integrate it into personalized care plans.

What Is Semaglutide / Cyanocobalamin Injection?

• This is a custom-compounded injectable formulation combining two active ingredients:

  1. Semaglutide – a GLP-1 receptor agonist known for appetite suppression, improved glucose control, and weight loss effects Empower Pharmacy+1

  2. Cyanocobalamin – a version of vitamin B12, important for energy metabolism, neurological function, and red blood cell production Empower Pharmacy+2Wikipedia+2

• Empower Pharmacy produces this injectable under their compounding operations and offers it through their 503A compounding pharmacy (patient-specific prescriptions) and 503B facility for larger sterile compounding needs Empower Pharmacy+3Empower Pharmacy+3Empower Pharmacy+3

• Because it’s a compounded product, it is not FDA-approved as a branded drug; its use must be based on a valid prescription and medical supervision Houston Chronicle+3Healthline+3Empower Pharmacy+3

How It Works: Mechanisms & Potential Benefits

Semaglutide Action

• Semaglutide mimics GLP-1 (glucagon-like peptide-1), helping to stimulate insulin when glucose is high, inhibit glucagon, slow gastric emptying, and reduce appetite Empower Pharmacy+2Mayo Clinic+2

• In clinical and observational data, semaglutide use has also been linked to favorable metabolic changes, cardiovascular benefits, and weight loss outcomes Wikipedia+3News-Medical+3PMC+3

Cyanocobalamin (Vitamin B12) Support

• Vitamin B12 plays essential roles in DNA synthesis, nerve function, red blood cell formation, and energy metabolism Empower Pharmacy+2Wikipedia+2

• Supplementing B12 alongside semaglutide could help mitigate fatigue or nutrient deficiencies that may accompany reduced appetite or dietary changes during weight loss Healthline+2Empower Pharmacy+2

Together, the idea is that the combined injection may offer dual benefit—addressing both metabolic appetite regulation (via semaglutide) and micronutrient support (via B12).

What the Evidence Shows (and What It Doesn’t)

• A recent real-world study (n = 94) on semaglutide + cyanocobalamin (compounded) showed average weight loss of ~4.11 kg (≈4.6%) in 3 months, along with favorable reductions in fat mass and improvements in body composition PubMed

• However, large controlled trials of this exact combination are lacking. Most robust evidence exists for semaglutide alone (or approved combinations) rather than compounded blends Healthline+2Empower Pharmacy+2

• Because it’s compounded, variability in formulation, potency, sterility, or stability is a valid concern. The FDA and medical community emphasize caution with compounded GLP-1s Healthline+2Houston Chronicle+2

• Notably, the FDA has ended certain emergency provisions allowing compounded semaglutide production, signaling that compounding may be restricted unless specific clinical justification is documented Empower Pharmacy+2Houston Chronicle+2

Pros, Risks & Monitoring

At Cleveland Care Clinic, we would approach this option only under strict oversight: starting with lower doses, frequent follow-ups, lab monitoring (e.g. metabolic panels, B12 levels), and patient education.

How Cleveland Care Clinic May Use This Option

1. Patient Evaluation – Full medical history, labs, comorbid conditions, contraindications screening

2. Informed Consent & Shared Decision – Discussion of pros, uncertainties, and monitoring plan

3. Personalized Dosing Plan – Titrating dose carefully to balance efficacy and tolerability

4. Comprehensive Support – Dietary, behavioral, activity coaching alongside injection therapy

5. Regular Monitoring – Tracking metabolic markers, side effects, weight, body composition

6. Adjustment or Transition – If compounded therapy is not ideal long-term, transition to FDA-approved alternatives when feasible

Who Might Be a Candidate?

• Patients who already qualify for GLP-1 therapy and would like additional support

• Individuals with suboptimal B12 levels or risk of deficiency

• Those who prefer combining metabolic and micronutrient therapy

• Patients fully committed to close medical oversight and follow-up

However, it’s not recommended if you have contraindications to GLP-1 agents, are pregnant, breastfeeding, have uncontrolled GI disease, or cannot adhere to monitoring and follow-up.

Final Thoughts & Caution

Compounded Semaglutide / Cyanocobalamin Injection is an intriguing, patient-tailored option that may offer metabolic plus micronutrient support in one shot. But it comes with important caveats: lack of FDA approval, variability risks, and transitional regulatory changes.

At Cleveland Care Clinic, we believe in balancing innovation with responsibility. Any use of this injection would be reserved for patients where the benefits outweigh the risks—and always under careful medical supervision.

If you’re curious whether this option could be right for your health journey, reach out to us for a consultation. We’ll help you navigate the choices and find the safest, most effective path forward.